Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia

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Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia.

PURPOSE To study the effects of sevoflurane and isoflurane on noradrenaline release from the rat preoptic area (POA). METHOD Sixteen male Wistar rats were studied. A microdialysis probe with a 2 mm long semipermeable membrane was implanted in the POA. Dialysates were collected at intervals often minutes. After obtaining five control samples for 50 min, 30 min inhalation of 3% sevoflurane or 1...

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GABAergic modulation of noradrenaline release caused by blood pressure changes in the rat median preoptic area

Experiments using in-vivo microdialysis methods were conducted to investigate whether blood pressure changes cause an alteration in the release of noradrenaline (NA) in the median preoptic nucleus (MnPO) and whether the γ-aminobutyric acid (GABA) receptor mechanism is involved in the modulation of the pressure response-induced alteration in the NA release. In urethane-anesthetized male rats, in...

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ژورنال

عنوان ژورنال: Canadian Journal of Anesthesia/Journal canadien d'anesthésie

سال: 2001

ISSN: 0832-610X,1496-8975

DOI: 10.1007/bf03028309